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KMID : 0654219920010000167
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Journal of Asan Welfare Foundation Haesung General Hospital
1992 Volume.1 No. 0 p.167 ~ p.174
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Effects of Ischemia,Reperfusion and Administration of Superoxide Dismutase and Catalase in Rat Jejunum on the Oxygen Toxicity
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Abstract
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Changes in activities of superoxide dismutase(EC 1.15.1.1, SOD), catalase(EC 1.11.1.6) and xanthine oxidase
ire observed arter treating rat´s jejunal segment with ischemia(group A), reperfusion(group B) and luminal ~nzyme(SOD 1,000 units+catalase 1,000 units/0.2 ml saline) injection followed by reperfusion(group Q. -The results were summarized as follows
In all experimental groups, the activity of Mn-SOD was similar to that in the control.
´ 2 The activity of Cu, Zn-SOD in group A and B was significantly higher than that in the control, but the activity in group C was similar to that in the control.
3. The activity of catalase in group A was significantly lower than that in the control, but group B and C were similar to that in the control.
4. The activity of xanthine oxidase was significantly higher in group A, similar in group B and significantly lower in group C, as compared with in the control.
The results suggest that ischemia could enhance the xanthine oxidase activity which leads to the production 6f oxygen radical in jejunum : reperfusion may recover the jejunum from the oxygen toxicity induced by ischemia : luminal injection of SOD and catalase may effectively protect the jejunum from the oxygen toxicity.
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KEYWORD
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